Supplemental Analysis for Optimizing Tactics for use of the U.S. Antiviral Strategic National Stockpile for Pandemic (H1N1) Influenza, 2009

We simulate the spread of disease within and between the 100 largest metropolitan areas in the United States. Disease is transmitted within cities according to a deterministic compartmental SEIR model (city model). Disease moves stochastically between cities via infected travelers (network model). In each simulation run we alternately simulate a week (i. e., 7 days) of disease transmission within each city using the city model and then simulate between-city transmission using the network model, as described below. This process is repeated for 53 weeks or until the disease dies out, whichever occurs first.